A couple of things to keep in mind–
If you are planning to be riding during “normal” commuting hours, there is going to be alot more going on to keep track of than riding on the weekend. Depending on how traffic in your area goes, you may be better off making your first couple of trips on the highway as weekend excursions to your buddy’s place rather than as part of the morning commute.
The other thing about the morning commute- unless you aren’t expected at the office at a set time, the time factor might end up being a very distracting stresser. If you want to do this, try to add 15-20 min into your commute time the first couple of days. That way if you get a late start or there is a traffic snarl, you won’t be worried about being late to work in addition to clutching and shifting and leaning and watching for surface hazards and and and and