Some carbureted bikes are more “cold blooded” than others due to lean factory jetting for emission reasons. GS500 is one example. My ’01 is not as bad as what owners of older models (slightly different carburetor design) describe, but even with temp in the high 50s, the engine would spit and buck at low rpm (not pretty) if you don’t let it warm up for a few minutes. Re-jetting the pilot jet to make it richer would cure this problem; I haven’t bothered w/ rejetting.
During my weekend rides I often go from sea level to close to 4,000 ft of elevation. No problem felt with my 2 carbureted bikes. I thought maybe you’d start to feel the power difference in a carbureted bike with something like 6,000 ft of elevation change. I ride with ambient temp from the 40s to over 100F and haven’t had the need to make any adjustment to the carburetors in my bikes.
FI is nice, but I wouldn’t hesitate buying a good carbureted bike.