The distance, yes teh bike can do it, but not comfortably at that speed (if the Rebel 250 is any indication).
I wouldn’t plan on sustained speeds about 65mph. And to be honest, you’ll probably not enjoy a trip at those speeds on the interstate for long periods. If you can take local highways the whole way home at 60mph you’ll enjoy yourself a lot more (to say nothing of the savings in gas).
And Six-shooter is right on the money when it comes to how long you will last. Motorcycles are far draining. I’m still at the stage where a 200mile day leaves me utterly spent. I always plan my rides thinking it is like spending that time in a car, but it isn’t. You are on alert the whole time, and that just drains you.
“The two seconds between ‘Oh S**!’ and the crash isn’t a lot of practice time.”